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	Provedor de dados BJMBR (5) Autor Moura Neto,V. (5) Cavalcante,L.A. (2) Garcia-Abreu,J. (2) Gomes,F.C.A. (2) Mendes,F.A. (2) Silva,L.C.F. (2) Aguiar,D.P. (1) Carvalho,S.L. (1) Duarte,M.E.L. (1) Martinez,R. (1) Onofre,G. (1) Onofre,G.R. (1) Paulin,D. (1) Spohr,T.C.L.S. (1) Weissmüller,G. (1) Werneck,C.C. (1) de Sousa,E.B. (1) dos Santos Junior,G.C. (1) Mais... Palavra-chave Astrocyte (2) Astrocytes (2) Midbrain (2) Axonal growth (1) CNS (1) Chondroitin sulfate (1) GFAP (1) GFAP gene (1) Glycosaminoglycans (1) Growth factors (1) Heparan sulfate (1) Intermediate filaments (1) Metabolomics (1) Midline (1) NMR (1) Nervous system (1) Neuron (1) Neuron-glia interaction (1) Neuron-glia interactions (1) Osteoarthritis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (5) Ano 2017 (1) 2003 (1) 2001 (2) 1999 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Astroglial cells derived from lateral and medial midbrain sectors differ in their synthesis and secretion of sulfated glycosaminoglycans BJMBR Onofre,G.R.; Werneck,C.C.; Mendes,F.A.; Garcia-Abreu,J.; Moura Neto,V.; Cavalcante,L.A.; Silva,L.C.F.. Astroglial cells derived from lateral and medial midbrain sectors differ in their abilities to support neuritic growth of midbrain neurons in cocultures. These different properties of the two types of cells may be related to the composition of their extracellular matrix. We have studied the synthesis and secretion of sulfated glycosaminoglycans (GAGs) by the two cell types under control conditions and ß-D-xyloside-stimulated conditions, that stimulate the ability to synthesize and release GAGs. We have confirmed that both cell types synthesize and secrete heparan sulfate and chondroitin sulfate. Only slight differences were observed between the proportions of the two GAGs produced by the two types of cells after a 24-h labeling period. However, a marked... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycosaminoglycans; Astrocytes; Neuron-glia interactions; Midbrain. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200014 Cross-talk between neurons and glia: highlights on soluble factors BJMBR Gomes,F.C.A.; Spohr,T.C.L.S.; Martinez,R.; Moura Neto,V.. The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership. Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuron-glia interaction; Trophic factors; Astrocyte; Neuron; Nervous system. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500008 Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation BJMBR Gomes,F.C.A.; Paulin,D.; Moura Neto,V.. Intermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a switch between vimentin and glial fibrillary acidic protein (GFAP) expression, with the latter being recognized as an astrocyte maturation marker. Levels of GFAP are regulated under developmental and pathological conditions. Upregulation of GFAP expression is one of the main characteristics of the astrocytic reaction commonly observed after CNS lesion. In this way, studies on GFAP regulation have been shown to be useful to understand not only brain physiology but... Tipo: Info:eu-repo/semantics/article Palavras-chave: CNS; Astrocyte; Growth factors; Intermediate filaments; GFAP; Vimentin; GFAP gene. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500016 Metabolomics as a promising tool for early osteoarthritis diagnosis BJMBR de Sousa,E.B.; dos Santos Junior,G.C.; Duarte,M.E.L.; Moura Neto,V.; Aguiar,D.P.. Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Metabolomics is an emerging field and has the potential to detect many metabolites in a single spectrum using high resolution nuclear magnetic resonance (NMR) techniques or mass spectrometry (MS). NMR is a reproducible and reliable non-destructive analytical method. On the other hand, MS has a lower detection limit and is more destructive, but it is more sensitive. NMR and MS are useful... Tipo: Info:eu-repo/semantics/article Palavras-chave: NMR; Metabolomics; Osteoarthritis; Synovial Fluid. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100301 Sulfated proteoglycans as modulators of neuronal migration and axonal decussation in the developing midbrain BJMBR Cavalcante,L.A.; Garcia-Abreu,J.; Mendes,F.A.; Moura Neto,V.; Silva,L.C.F.; Onofre,G.; Weissmüller,G.; Carvalho,S.L.. Proteoglycans are abundant in the developing brain and there is much circumstantial evidence for their roles in directional neuronal movements such as cell body migration and axonal growth. We have developed an in vitro model of astrocyte cultures of the lateral and medial sectors of the embryonic mouse midbrain, that differ in their ability to support neuritic growth of young midbrain neurons, and we have searched for the role of interactive proteins and proteoglycans in this model. Neurite production in co-cultures reveals that, irrespective of the previous location of neurons in the midbrain, medial astrocytes exert an inhibitory or nonpermissive effect on neuritic growth that is correlated to a higher content of both heparan and chondroitin sulfates... Tipo: Info:eu-repo/semantics/article Palavras-chave: Astrocytes; Axonal growth; Chondroitin sulfate; Heparan sulfate; Midline; Midbrain. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800005 Registros recuperados: 5 Primeira ... 1 ... Última

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